Journal Article

Relationship of Kaposi Sarcoma (KS)-Associated Herpesvirus Viremia and KS Disease in Zimbabwe

Thomas B. Campbell, Margaret Borok, Irene E. White, Ivy Gudza, Buxton Ndemera, Albert Taziwa, Adriana Weinberg and Lovemore Gwanzura

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 9, pages 1144-1151
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374599
Relationship of Kaposi Sarcoma (KS)-Associated Herpesvirus Viremia and KS Disease in Zimbabwe

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The relationship between Kaposi sarcoma-associated herpesvirus (KSHV) viremia and KS disease was investigated in 500 subjects who received treatment in Harare, Zimbabwe. Subjects were grouped by results of human immunodeficiency virus (HIV) type 1 serological tests, KS diagnosis, and KS clinical stage. The plasma KSHV DNA concentration was associated with concomitant KS and HIV-1 infection (AIDS-KS; P < .001) and AIDS-KS clinical stage (P = .01). Plasma KSHV DNA levels were greater in AIDS-KS than in matched HIV-1-seronegative KS (P = .04). The plasma KSHV DNA level was not associated with age, sex, systemic symptoms, or CD4+ lymphocyte count. Plasma and peripheral blood mononuclear cell KSHV DNA concentrations were linearly related (r2 = .44; P < .001), and the nucleotide sequence of the K1 gene highly variable region was identical in both compartments. These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection.

Journal Article.  4579 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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