Journal Article

Parvovirus B19 Encephalitis Presenting as Immune Restoration Disease after Highly Active Antiretroviral Therapy for Human Immunodeficiency Virus Infection

Richard C. Nolan, Glenys Chidlow and Martyn A. French

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 9, pages 1191-1194
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374603
Parvovirus B19 Encephalitis Presenting as Immune Restoration Disease after Highly Active Antiretroviral Therapy for Human Immunodeficiency Virus Infection

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Illness occurring during the initial months of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection may be a consequence of the restoration of an immune response against opportunistic pathogens (i.e., immune restoration disease [IRD]). We describe a young man who had AIDS complicated by parvovirus B19 infection and RBC aplasia and who developed a painless, progressive dyspraxia of the left arm and an expressive dysphasia 4 weeks after commencing effective HAART. Neuroimaging demonstrated multiple right fronto-parietal lesions, and, following extensive investigations, including a brain biopsy, it was concluded that the brain lesions represented IRD associated with parvovirus B19 infection.

Journal Article.  2287 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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