Journal Article

Epstein-Barr Virus and Human Herpesvirus 8 Coinfection and Concomitant Extranodal Nasal-Type NK/T Cell Lymphoma and Castleman Disease: Case Report

Claire Larroche, Félix Agbalika, Hélène Poirel, Antoine Martin, Agnès Gautheret-Dejean, Martine Raphaël and Olivier Lortholary

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 9, pages e107-e110
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374663
Epstein-Barr Virus and Human Herpesvirus 8 Coinfection and Concomitant Extranodal Nasal-Type NK/T Cell Lymphoma and Castleman Disease: Case Report

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We describe a 36-year-old man uninfected with human immunodeficiency virus who had confirmed concurrent infection with Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) and their respective lymphoproliferative manifestations, nasal-type NK/T cell lymphoma and Castleman disease. Antibodies to HHV-8 and EBV DNA were found in plasma and peripheral blood mononuclear cells. An EBV-positive nasal-type NK/T cell lymphoma infiltrated the splenic red pulp, whereas the white pulp contained HHV-8-positive plasmablasts, as found in Castleman disease.

Journal Article.  1576 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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