Journal Article

Management of Severely Immunocompromised Human Immunodeficiency Virus Type 1—Infected African Orphans with Structured Treatment Interruption: Another Kind of Salvage Therapy

Rana Chakraborty, Rachel Musoke, Tresa Palakudy, Alexandra Cross and Angelo D Agostino

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 11, pages 1483-1485
Published in print June 2003 | ISSN: 1058-4838
Published online June 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374848
Management of Severely Immunocompromised Human Immunodeficiency Virus Type 1—Infected African Orphans with Structured Treatment Interruption: Another Kind of Salvage Therapy

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Without an effective therapeutic human immunodeficiency virus (HIV)-1 vaccine, providing cost-effective, minimally toxic antiretroviral therapy to the many individuals already infected with HIV-1 is a global priority. Implementation of a structured treatment interruption (STI) regimen may be a promising intervention for HIV-1 infection. We adopted this approach out of necessity for 3 severely immunocompromised African children naive to therapy, and increases in the T lymphocyte count and improved quality and sustainability of life 2 years after initiation of the STI regimen were noted.

Journal Article.  1263 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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