Journal Article

<i>Mycoplasma hominis</i> Lipid-Associated Membrane Protein Antigens for Effective Detection of <i>M. hominis</i>-Specific Antibodies in Humans

Shyh-Ching Lo, Richard Y.-H. Wang, Teresa Grandinetti, Nianxiang Zou, Christine L.-D. Haley, Michael M. Hayes, Douglas J. Wear and James W.-K. Shih

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 10, pages 1246-1253
Published in print May 2003 | ISSN: 1058-4838
Published online May 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374851
Mycoplasma hominis Lipid-Associated Membrane Protein Antigens for Effective Detection of M. hominis-Specific Antibodies in Humans

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Lipid-associated membrane proteins (LAMPs) from 14 Mycoplasma hominis isolates or strains share similar protein and antigenicity profiles. Of 31 human immunodeficiency virus-infected patients from whose samples M. hominis was cultured, 28 tested strongly positive for serum antibodies to M. hominis LAMPs. The remaining 3 serum samples showed low antibody titer to LAMPs from all of the 14 M. hominis isolates or strains, which was likely the result of the compromised immune systems of the patients. Thus, M. hominis LAMPs as a whole are homogenous in antigenicity within the species, despite having many different serotypes. Serological study involving 564 healthy blood donors and 211 patients attending sexually transmitted disease clinics by LAMPs showed that general populations were widely exposed to M. hominis. Women were infected with M. hominis at a younger age than were men. The prevalence of infection increased markedly among sexually active persons.

Journal Article.  4303 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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