Journal Article

Natural and Nosocomial Infection in a Patient with West Nile Encephalitis and Extrapyramidal Movement Disorders

Tom Solomon, Ann F. Fisher, David W. C. Beasley, Pitchaiah Mandava, Bruno P. Granwehr, Hans Langsjoen, Amelia P. Travassos Da Rosa, Alan D. T. Barrett and Robert B. Tesh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 11, pages e140-e145
Published in print June 2003 | ISSN: 1058-4838
Published online June 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/374936
Natural and Nosocomial Infection in a Patient with West Nile Encephalitis and Extrapyramidal Movement Disorders

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Since its first recognition in North America in 1999, West Nile virus (WNV) has spread rapidly across the continent, but in many communities, rapid diagnostic tests for detection of WNV infection are not fully available. We describe a patient with extrapyramidal movement disorders and changes in the basal ganglia noted on magnetic resonance images that are characteristic of other flavivirus encephalitides and may help in the recognition of patients with West Nile encephalitis. Detailed molecular analysis suggested that, although our patient received a blood transfusion infected with WNV, the virus that caused his initial infection and encephalitis was probably acquired naturally from a mosquito.

Journal Article.  3318 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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