Journal Article

Comparison of 2 Regimens that Include Interferon-α-2a plus Ribavirin for Treatment of Chronic Hepatitis C in Human Immunodeficiency Virus—Coinfected Patients

Didier Neau, Pascale Trimoulet, Maria Winnock, Anne Rullier, Brigitte Le Bail, Denis Lacoste, Jean-Marie Ragnaud, Paulette Bioulac Sage, Marie-Edith Lafon, Geneviève Chêne and Michel Dupon

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 12, pages 1564-1571
Published in print June 2003 | ISSN: 1058-4838
Published online June 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375067
Comparison of 2 Regimens that Include Interferon-α-2a plus Ribavirin for Treatment of Chronic Hepatitis C in Human Immunodeficiency Virus—Coinfected Patients

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

An open-label, randomized trial was conducted to compare the efficacy and safety of 2 regimens of interferon-α-2a (IFN-α-2a) plus ribavirin for management of chronic hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)–coinfected patients. Sixty-eight patients were randomized to receive IFN-α-2a at a dosage of either (1) 6 MU given 3 times per week for 24 weeks, followed by 3 MU 3 times per week for an additional 24 weeks (group A; 31 patients); or (2) 9 MU per day for 2 weeks, followed by 3 MU per day for 22 weeks, followed by 3 MU 3 times per week for 24 weeks (group B; 37 patients). Ribavirin was added at week 16 of therapy if HCV RNA remained detectable at week 12. Sustained virological response was achieved in 10 patients (15%; 6 in group A and 4 in group B). HCV genotypes 2 or 3 and a decrease in the HCV load of ≤3 log10 copies/mL between inclusion and week 4 were associated with virological response. In conclusion, the combination of conventional IFN-α-2a and ribavirin has poor virological efficacy in HCV-HIV–coinfected patients.

Journal Article.  4511 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.