Journal Article

Isolated Antibody to Hepatitis B Core Antigen in Human Immunodeficiency Virus Type-1—Infected Individuals

Rajesh T. Gandhi, Alysse Wurcel, Hang Lee, Barbara McGovern, Melinda Boczanowski, Roslyn Gerwin, Colleen P. Corcoran, Zbigniew Szczepiorkowski, Sarah Toner, Daniel E. Cohen, Paul E. Sax and Chinweike Ukomadu

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 36, issue 12, pages 1602-1605
Published in print June 2003 | ISSN: 1058-4838
Published online June 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375084
Isolated Antibody to Hepatitis B Core Antigen in Human Immunodeficiency Virus Type-1—Infected Individuals

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We screened 651 human immunodeficiency virus (HIV)-1–infected subjects for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B surface antigen (anti-HBs). Of a total of 387 subjects who tested negative for both HBsAg and anti-HBs, 142 underwent further testing for isolated presence of antibody to hepatitis B core antigen (anti-HBc). Of these 142 subjects, 60 (42%) tested positive for anti-HBc (isolated anti-HBc). Individuals coinfected with HIV-1 and hepatitis C virus (HCV) were more likely to have isolated anti-HBc than were subjects with HIV-1 alone (80% vs. 16%, respectively). Our findings suggest that individuals with HIV-1/HCV coinfection for whom there is no serological evidence for hepatitis B virus when screened with HBsAg and anti-HBs will be positive for anti-HBc in >75% of cases. A screening strategy that tests only for HBsAg and anti-HBs in HIV-1–infected patients will miss a large number of individuals with isolated anti-HBc.

Journal Article.  2484 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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