Journal Article

Diagnosis of Enterovirus Infection in the First 2 Months of Life by Real-Time Polymerase Chain Reaction

M. A. Verboon-Maciolek, M. Nijhuis, A. M. van Loon, N. van Maarssenveen, H. van Wieringen, M. A. Pekelharing-Berghuis, T. G. Krediet, L. J. Gerards, A. Fleer, R. J. A. Diepersloot and S. F. T. Thijsen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 1, pages 1-6
Published in print July 2003 | ISSN: 1058-4838
Published online July 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375222
Diagnosis of Enterovirus Infection in the First 2 Months of Life by Real-Time Polymerase Chain Reaction

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During summer and fall, enterovirus infections are responsible for a considerable proportion of hospitalizations of young infants. We prospectively studied the incidence of enterovirus infections via real-time polymerase chain reaction (PCR) in blood, feces, and cerebrospinal fluid samples from infants <60 days old who had received a clinical diagnosis of sepsis. Forty-five patients were included: 19 were admitted to the pediatric wards of 2 general hospitals, and 26 had been hospitalized since birth in the neonatal intensive care unit (NICU) of a tertiary care hospital. None of the NICU patients developed enteroviral disease. In contrast, an enterovirus was detected in 11 (58%) of the patients admitted to the 2 general hospitals, 10 of whom (53%) showed evidence of systemic infection. Enterovirus infections are an important cause of sepsis in infants admitted to the hospital. Real-time PCR in serum was a rapid and sensitive method for diagnosis of enterovirus infection.

Journal Article.  3204 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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