Journal Article

Interleukin-12 Receptor β1 Deficiency Presenting as Recurrent <i>Salmonella</i> Infection

Orna Staretz-Haham, Rimma Melamed, Matitiahu Lifshitz, Nurith Porat, Claire Fieschi, Jean Laurent Casanova and Jacov Levy

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 1, pages 137-140
Published in print July 2003 | ISSN: 1058-4838
Published online July 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375229
Interleukin-12 Receptor β1 Deficiency Presenting as Recurrent Salmonella Infection

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We describe a child with interleukin-12 receptor β1 (IL-12Rβ1) deficiency caused by a homozygous IL12RB1 large deletion who presented at the age of 1 year with recurrent, often asymptomatic episodes of bacteremia caused by group D Salmonella species. No mycobacterial disease or other unusual infection was present. The episodes of salmonellosis were caused by an identical serovar during a period of 18 months. This is the first case of inherited IL-12Rβ1 deficiency diagnosed after isolated, recurrent salmonellosis.

Journal Article.  2793 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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