Journal Article

Clinical and Bacteriological Characteristics of IMP-Type Metallo-β-Lactamase-Producing <i>Pseudomonas aeruginosa</i>

Yoichi Hirakata, Toshiyuki Yamaguchi, Michiko Nakano, Koichi Izumikawa, Mariko Mine, Shiho Aoki, Akira Kondoh, Junichi Matsuda, Mitsukuni Hirayama, Katsunori Yanagihara, Yoshitsugu Miyazaki, Kazunori Tomono, Yasuaki Yamada, Shimeru Kamihira and Shigeru Kohno

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 1, pages 26-32
Published in print July 2003 | ISSN: 1058-4838
Published online July 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375594
Clinical and Bacteriological Characteristics of IMP-Type Metallo-β-Lactamase-Producing Pseudomonas aeruginosa

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IMP-type metallo-β-lactamase-producing bacteria have recently emerged worldwide. We conducted a case-control study in which 69 inpatients harboring blaIMP-positive Pseudomonas aeruginosa and 247 control subjects with blaIMP-negative pathogens were investigated. Prolonged hospitalization, antineoplastic chemotherapy, corticosteroid therapy (P =.001), and indwelling urinary catheters (P =.04) were risk factors for isolation of blaIMP-positive pathogens. The predominant source was urine (P =.001). The duration of antibiotic treatment and the total dose (including of carbapenems) were significantly greater among case patients than among control subjects (P <.01). blaIMP-positive P. aeruginosa isolates were more frequently resistant to multiple drugs (P =.001) and caused more infections (P =.001) than blaIMP-negative pathogens. There were no significant differences in bacteriological outcome (P =.94); however, infection-related death was more frequent among case patients than among control subjects (P =.023). These results suggest that precautionary measures against the spread of blaIMP-positive isolates are needed, because, for most of such pathogens, no antibiotic is potent enough to be used as a single agent in treatment of infection.

Journal Article.  3966 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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