Journal Article

Genetic Confirmation of Atovaquone-Proguanil–Resistant <i>Plasmodium falciparum</i> Malaria Acquired by a Nonimmune Traveler to East Africa

Eli Schwartz, Shay Bujanover and Kevin C. Kain

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 3, pages 450-451
Published in print August 2003 | ISSN: 1058-4838
Published online August 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375599
Genetic Confirmation of Atovaquone-Proguanil–Resistant Plasmodium falciparum Malaria Acquired by a Nonimmune Traveler to East Africa

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We report a case of atovaquone-proguanil–resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

Journal Article.  1003 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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