Journal Article

A Hospitalwide Intervention Program to Optimize the Quality of Antibiotic Use: Impact on Prescribing Practice, Antibiotic Consumption, Cost Savings, and Bacterial Resistance

Carlos Bantar, Beatriz Sartori, Eduardo Vesco, Claudia Heft, Mariano Saúl, Francisco Salamone and María Eugenia Oliva

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 2, pages 180-186
Published in print July 2003 | ISSN: 1058-4838
Published online July 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375818
A Hospitalwide Intervention Program to Optimize the Quality of Antibiotic Use: Impact on Prescribing Practice, Antibiotic Consumption, Cost Savings, and Bacterial Resistance

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Several findings from Argentina provide compelling evidence of the need for more rational use of antimicrobial agents. Thus, a multidisciplinary antimicrobial treatment committee for the development of a hospital-wide intervention program was formed to optimize the quality of antibiotic use in hospitals. Four successive steps were developed during 6-month periods: baseline data collection, introduction of a prescription form, education, and prescribing control. Sustained reduction of drug consumption was shown during the study (R2 = 0.6885; P = .01). Total cost savings was US$913,236. To estimate the consumption of R2p0.6885 Pp.01 cefepime and aminopenicillin-sulbactam in relation to that of the third-generation cephalosporins, 2 indices were calculated: Icfp and Iams, respectively. Decreasing resistance to ceftriaxone by Proteus mirabilis and Enterobacter cloacae proved to be associated with increasing Icfp. Decreasing rates of methicillin-resistant Staphylococcus aureus were related to increasing Iams. The present study indicates that a systematic program performed by a multidisciplinary team is a cost-effective strategy for optimizing antibiotic prescribing.

Journal Article.  3862 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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