Journal Article

Difficulties in Understanding the Metabolic Complications of Acquired Immune Deficiency Syndrome

Carl Grunfeld and Phyllis Tien

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue Supplement_2, pages S43-S46
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375886
Difficulties in Understanding the Metabolic Complications of Acquired Immune Deficiency Syndrome

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

With the introduction of combination antiretroviral therapy, changes in fat distribution and serummetabolites were reported. These included increased central fat (“buffalo hump,” abdominal, and visceral); decreased peripheral fat (in the face, legs, and arms); increased levels of triglycerides, low-density lipoprotein and total cholesterol, glucose, and insulin; and low levels of high-density lipoprotein cholesterol. Many of these changes predict increased atherosclerosis. It has been proposed that these findings are part of a single syndrome, much like metabolic syndrome. Our data indicate that many of these changes are independent. Some changes are antiretroviral drug (but not necessarily class)—specific, some represent the restoration to health, and others are due to effects of the host response to human immunodeficiency virus itself.

Journal Article.  3299 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.