Journal Article

Role of Acquired Immune Deficiency Syndrome—Defining Conditions in Human Immunodeficiency Virus—Associated Wasting

C. A. Wanke, M. Silva, A. Ganda, J. Fauntleroy, D. Spiegelman, T. A. Knox and S. L. Gorbach

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue Supplement_2, pages S81-S84
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/375894
Role of Acquired Immune Deficiency Syndrome—Defining Conditions in Human Immunodeficiency Virus—Associated Wasting

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To evaluate the contribution of acquired immune deficiency syndrome–defining conditions (ADCs) in human immunodeficiency virus (HIV)–associated wasting, we analyzed longitudinal data from 671 participants in a nutrition and HIV cohort study. Data on ADCs, height, and weight were collected at baseline and during 6 monthly study visits. The frequency of ADCs decreased over time, but the relative risk (RR) of wasting (decrease in body mass index [BMI] to <20 kg/m2) increased with a history of >1 ADC; the RR of wasting increased 1.3-fold with each additional historical ADC. Any ADC during the 6 months prior to a study visit was associated with a decrease in BMI to <20 kg/m2. The risk of wasting increased 2.7-fold with each additional recent ADC. These risks were not altered when adjusted for socioeconomic status, CD4 cell count, energy intake, or baseline BMI. Although ADCs contribute to the development of wasting, their contribution is relatively small.

Journal Article.  2101 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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