Journal Article

Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis

William J. Steinbach and David A. Stevens

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue Supplement_3, pages S157-S187
Published in print October 2003 | ISSN: 1058-4838
Published online October 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/376523
Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis

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The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal. Previously there were only 2 antifungals with activity against Aspergillus, but over the last few years there has been an explosion of newer agents and reformulations of older antifungals. Exploration has also begun with immunotherapy, with use of cytokines and granulocyte transfusions alone or in combination with antifungal therapy. This review will detail the available in vitro, in vivo, and clinical experience with the newer antifungal and immunomodulatory therapies in development for treatment of invasive aspergillosis.

Journal Article.  28579 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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