Journal Article

Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation

Man-Fung Yuen, Erwin Sablon, Danny Ka-Ho Wong, He-Jun Yuan, Benjamin Chun-Yu Wong, Annie On-On Chan and Ching-Lung Lai

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 4, pages 593-597
Published in print August 2003 | ISSN: 1058-4838
Published online August 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/376988
Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation

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Hepatitis B virus (HBV) genotypes and precore and core promoter mutations were determined in 318 patients with HBV. Patients infected with HBV genotype B had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with HBV genotype C (all P < .001). By logistic regression analysis, HBV genotype B infection (P = .014) and low albumin levels (P = .006) were independently associated with a higher risk of hepatic decompensation during severe exacerbations of disease. Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P = .05).

Journal Article.  2348 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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