Journal Article

Detection and Quantification of <i>Mycoplasma genitalium</i> in Male Patients with Urethritis

Nicolas Dupin, Gérard Bijaoui, Michaël Schwarzinger, Pauline Ernault, Philippe Gerhardt, Randa Jdid, Salim Hilab, Christina Pantoja, Marc Buffet, Jean-Paul Escande and Jean-Marc Costa

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 4, pages 602-605
Published in print August 2003 | ISSN: 1058-4838
Published online August 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/376990
Detection and Quantification of Mycoplasma genitalium in Male Patients with Urethritis

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Detection and quantification of Mycoplasma genitalium were evaluated in 83 patients with urethritis (group 1), 60 patients with urethral symptoms but no urethritis (group 2), and 50 asymptomatic men (group 3). Quantification of M. genitalium was carried out using real-time polymerase chain reaction (PCR) analysis of first-pass urine samples. The rate of detection of M. genitalium was significantly higher in group 1 than in groups 2 and 3 (P < .0001). The mean observed concentration of M. genitalium was 1.2 × 104 equivalent genomes/mL of urine (range, 50 to 8 × 104 equivalent genomes/mL). Analysis of M. genitalium load in serial urine samples collected before and after the administration of antibacterial treatment showed an association between clinical and microbiological responses, with a shift to negative PCR results in symptom-free patients. Our results illustrate the usefulness of monitoring the M. genitalium load in evaluating the susceptibility of M. genitalium to antibacterial treatment.

Journal Article.  1852 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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