Journal Article

Factors Associated with Maintenance of Long-Term Plasma Human Immunodeficiency Virus RNA Suppression

Scott D. Holmberg, Merle E. Hamburger, Anne C. Moorman, Kathy C. Wood and Frank J. Palella

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 5, pages 702-707
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/376992
Factors Associated with Maintenance of Long-Term Plasma Human Immunodeficiency Virus RNA Suppression

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To analyze factors associated with long-term (⩾2 years) suppression of virus load (VL), we performed a nested case-control analysis of 1235 Human Immunodeficiency Virus Outpatient Study cohort participants who were well characterized by multiple VL and CD4+ cell count determinations. Of these patients, 286 (23.1%) had maintained undetectable VLs (i.e., <400 copies/mm3 or <50 copies/mm3) for ⩾2 years. Being treatment naive at the start of antiretroviral therapy was associated with a greater likelihood of achieving long-term suppression of VL (odds ratio [OR], 1.5; 95% confidence interval, 1.0–2.0; P = .028). In multivariate models, abacavir, indinavir, efavirenz, and drug combinations that included both lamivudine and indinavir were the most effective treatments for achieving long-term suppression of VL (adjusted OR for each, >3.6; P value for each, <.01). Long-term suppression of VL is more likely in treatment-naive than in treatment-experienced patients, but there were several drugs—abacavir, efavirenz, indinavir, and drug combinations including lamivudine and indinavir—that appeared to be effective, whether they were part of a first or subsequent drug regimen.

Journal Article.  3477 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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