Journal Article

Voriconazole Concentrations in the Cerebrospinal Fluid and Brain Tissue of Guinea Pigs and Immunocompromised Patients

Irja Lutsar, Sarah Roffey and Peter Troke

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 5, pages 728-732
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/377131
Voriconazole Concentrations in the Cerebrospinal Fluid and Brain Tissue of Guinea Pigs and Immunocompromised Patients

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We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1–10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 μg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46).

Journal Article.  2440 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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