Journal Article

Molecular Epidemiology and Drug Resistance of <i>Mycobacterium tuberculosis</i> Isolates in the Archangel Prison in Russia: Predominance of the W-Beijing Clone Family

Olga S. Toungoussova, Andrey Mariandyshev, Gunnar Bjune, Per Sandven and Dominique A. Caugant

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 5, pages 665-672
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/377205
Molecular Epidemiology and Drug Resistance of Mycobacterium tuberculosis Isolates in the Archangel Prison in Russia: Predominance of the W-Beijing Clone Family

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Prisons play a significant role in the epidemiology of drug-resistant tuberculosis. A total of 114 Mycobacterium tuberculosis isolates recovered from patients in the Archangel prison (Archangel, Russia) in 2001 were studied using restriction fragment-length polymorphism analysis and spoligotyping. Drug susceptibility was analyzed by the radiometric broth method (BACTEC; Becton Dickinson Diagnostic Systems). According to genotyping studies, 87 (76.3%) of the isolates belonged to the W-Beijing family. Nearly all (96.6%) W-Beijing isolates were part of a cluster, whereas only 25.9% of the other isolates were clustered (P < .001). The largest cluster comprised 43 patients. Multidrug resistance was high among new (34.0%) and previously treated (55.0%) cases. Resistance to ethambutol (OR, 3.4; 95% CI, 1.0–12.7; P = .03) and streptomycin (OR, 4.2; 95% CI, 1.5–11.6; P = .001) was significantly associated with infection with W-Beijing isolates. Tuberculosis due to drug-resistant W-Beijing isolates is a major problem in the Archangel prison.

Journal Article.  4243 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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