Journal Article

Dilated Cardiomyopathy in an Adult Human Immunodeficiency Virus Type 1–Positive Patient Treated with a Zidovudine-Containing Antiretroviral Regime

Junko Tanuma, Azumi Ishizaki, Hiroyuki Gatanaga, Yoshimi Kikuchi, Satoshi Kimura, Michiaki Hiroe and Shinichi Oka

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 7, pages e109-e111
Published in print October 2003 | ISSN: 1058-4838
Published online October 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/377609
Dilated Cardiomyopathy in an Adult Human Immunodeficiency Virus Type 1–Positive Patient Treated with a Zidovudine-Containing Antiretroviral Regime

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We describe an adult woman infected with human immunodeficiency virus type 1 (HIV-1) who developed dilated cardiomyopathy (DCM) with histologically confirmed mitochondrial damage while receiving anti—HIV-1 combination therapy that included nelfinavir, lamivudine, and zidovudine. DCM resolved after discontinuation of the regimen, and cardiac function remained normal after initiation of treatment with nelfinavir, lamivudine, and abacavir, which indicates that DCM was induced by mitochondrial toxicity, most likely caused by zidovudine.

Journal Article.  1097 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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