Journal Article

<i>Neisseria meningitidis</i> Strains Isolated from Invasive Infections in France (1999–2002): Phenotypes and Antibiotic Susceptibility Patterns

Aude Antignac, Magaly Ducos-Galand, Annie Guiyoule, René Pirès, Jean-Michel Alonso and Muhamed-Kheir Taha

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 7, pages 912-920
Published in print October 2003 | ISSN: 1058-4838
Published online October 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/377739
Neisseria meningitidis Strains Isolated from Invasive Infections in France (1999–2002): Phenotypes and Antibiotic Susceptibility Patterns

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Infections due to Neisseria meningitidis are a major public health concern. In France, during 1999–2002, a total of 2167 clinical isolates of N. meningitidis from invasive infections were studied at the National Reference Center for Meningococci (Paris). Serogroup B strains were the most common (58%), followed by serogroup C strains (29%) and serogroup W135 strains (8%). Various phenotypes were observed, reflecting heterogeneity in the meningococcal population. Strains were susceptible to antibiotics currently used for treatment and chemoprophylaxis of meningococcal infections. However, the prevalence of meningococci with reduced susceptibility to penicillin is increasing. Such strains were heterogeneous and accounted for ∼30% of isolates during this period, warranting continued surveillance of this phenomenon.

Journal Article.  3562 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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