Journal Article

Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

Wei Cui, Ying Fan, Wei Wu, Feng Zhang, Jun-ying Wang and An-ping Ni

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 6, pages 857-859
Published in print September 2003 | ISSN: 1058-4838
Published online September 2003 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/378587
Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

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In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4+ T lymphocyte levels were reduced in 100% of patients, CD8+ T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.

Journal Article.  1862 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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