Journal Article

Group A Streptococcal Infections in Sweden: A Comparative Study of Invasive and Noninvasive Infections and Analysis of Dominant T28 <i>emm</i>28 Isolates

Björn K. G. Eriksson, Mari Norgren, Karen McGregor, Brian G. Spratt and Birgitta Henriques Normark

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 9, pages 1189-1193
Published in print November 2003 | ISSN: 1058-4838
Published online November 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/379013
Group A Streptococcal Infections in Sweden: A Comparative Study of Invasive and Noninvasive Infections and Analysis of Dominant T28 emm28 Isolates

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Surveillance of group A streptococcus (GAS) infections in Sweden during 1996–1997 indicated that T28 isolates were dominant, whereas T1M1 infections were uncommon. Circulating T28 isolates were nearly all emm28, MLST52, and these clones had also been prevalent 10 years earlier. Isolates from invasive and noninvasive infections were of similar types and prevalences. The average national incidence of invasive episodes was 2.9/100,000 population but varied between 0 and 8.3/100,000 population in different counties. It increased markedly with age, reaching 22.9 episodes/100,000 among people aged ⩾90 years. The incidence of puerperal sepsis was higher than expected (22.4/100,000 of those at risk), with 1 death. Overall mortality was 16% and was associated with preexisting chronic disease (P = .002). Streptococcal toxic shock syndrome (STSS) developed in ∼15% of patients with invasive episodes, with a mortality rate of 45%. The use of nonsteroidal anti-inflammatory drugs was not found to be associated with the development of STSS.

Journal Article.  2805 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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