Journal Article

Invasive Pneumococcal Disease in Scotland, 1999–2001: Use of Record Linkage to Explore Associations between Patients and Disease in Relation to Future Vaccination Policy

Moe H. Kyaw, Peter Christie, Stuart C. Clarke, John D. Mooney, Syed Ahmed, Ian G. Jones and Harry Campbell

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 10, pages 1283-1291
Published in print November 2003 | ISSN: 1058-4838
Published online November 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/379016
Invasive Pneumococcal Disease in Scotland, 1999–2001: Use of Record Linkage to Explore Associations between Patients and Disease in Relation to Future Vaccination Policy

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A record linkage study was done to provide comprehensive data on the epidemiologic characteristics of invasive pneumococcal disease (IPD) in Scotland. The overall incidence of IPD was 11 cases/105 persons and 21 cases/105 persons <1 year of age, 51 cases/105 persons 1 year of age, 45 cases/105 elderly persons (age ⩾65 years), 176–483 cases/105 persons with chronic medical conditions, and 562–2031 cases/105 persons with severe immunosuppression. The case-fatality rate was 11% among elderly persons and ranged from 3% to 13% among persons with underlying medical conditions. The most common pneumococcal serogroups associated with IPD were 14, 9, 6, 19, 23, 8, and 4. Serogroups included in the 23-valent polysaccharide vaccine caused the majority of cases of IPD. The proportion of IPD due to the 7-, 9-, and 11-valent conjugate vaccine serogroups was lower among older people and persons with underlying medical conditions.

Journal Article.  4157 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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