Journal Article

Incident Hepatitis C Virus in Women with Human Immunodeficiency Virus Infection

M. Augenbraun, J. J. Goedert, D. Thomas, J. Feldman, E. C. Seaberg, A. L. French, E. Robison, M. Nowicki and N. Terrault

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 10, pages 1357-1364
Published in print November 2003 | ISSN: 1058-4838
Published online November 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/379075
Incident Hepatitis C Virus in Women with Human Immunodeficiency Virus Infection

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Individuals infected with human immunodeficiency virus type 1 (HIV-1) are frequently coinfected with hepatitis C virus (HCV). Acute HCV infection is often asymptomatic and poorly understood. We conducted a historical prospective study of HCV antibody and viremia in plasma samples obtained during 1994–1999 from a cohort of initially HIV-1–infected, HCV-uninfected women and from HIV-1–HCV–uninfected women. Twenty-two (1.5%) of 1517 experienced seroconversion. Of these, 14 (64%) truly acquired a new infection as assessed by enzyme immunoassay response and new-onset viremia. The incidence rate in HIV-1–infected women was 2.7 cases per 1000 person-years; it was 3.3 cases per 1000 person-years in HIV-1–seronegative women (relative risk, 1.21; P = .75). Acquisition of HCV was associated with any history of drug use (P < .01). Five of 12 viremic, seroconverting individuals cleared viremia. Incident HCV infection among HIV-1–infected and HIV-1–uninfected women was low. It was linked to drug use and commonly resolved.

Journal Article.  4190 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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