Journal Article

Is Methicillin-Resistant <i>Staphylococcus aureus</i> More Virulent than Methicillin-Susceptible <i>S. aureus?</i> A Comparative Cohort Study of British Patients with Nosocomial Infection and Bacteremia

M. Melzer, S. J. Eykyn, W. R. Gransden and S. Chinn

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 11, pages 1453-1460
Published in print December 2003 | ISSN: 1058-4838
Published online December 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/379321
Is Methicillin-Resistant Staphylococcus aureus More Virulent than Methicillin-Susceptible S. aureus? A Comparative Cohort Study of British Patients with Nosocomial Infection and Bacteremia

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Staphylococcus aureus is the most common cause of hospital-acquired bacteremia. From 1995 through 2000, data on age, sex, patient specialty at time of first bacteremia, primary and secondary sites of infection, delay in initiating antimicrobial therapy, and patient outcome were prospectively recorded for 815 patients with nosocomial S. aureus bacteremia. The proportion of patients whose death was attributable to methicillin-resistant S. aureus (MRSA) was significantly higher than that for methicillin-susceptible S. aureus (MSSA) (11.8% vs. 5.1%; odds ratio [OR], 2.49; 95% confidence interval [CI], 1.46–4.24; P < .001). After adjustment for host variables, the OR decreased to 1.72 (95% CI, 0.92–3.20; P = .09). There was no significant difference between rates of disseminated infection (7.1% vs. 6.2% for MRSA-infected patients and MSSA-infected patients, respectively; P = .63), though the rate of death due to disseminated infection was significantly higher than death due to uncomplicated infection (37% vs. 10% for MRSA-infected patients [P < .001] and 37% vs. 3% for MSSA-infected patients [P < .001]). There was a strong statistical trend toward death due to nosocomial MRSA infection and bacteremia, compared with MSSA.

Journal Article.  3534 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.