Journal Article

The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics

Maureen Lynch, Wun-Ju Shieh, Kathleen Tatti, Jon R. Gentsch, Tara Ferebee Harris, Baoming Jiang, Jeannette Guarner, Joesph S. Bresee, Margaret Greenwald, Steve Cullen, H. D. Davies, Cynthia Trevenen, Sherif R. Zaki and Roger I. Glass

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 10, pages 1327-1333
Published in print November 2003 | ISSN: 1058-4838
Published online November 2003 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/379322
The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics

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Rotavirus, the most common cause of severe, dehydrating gastroenteritis among children worldwide, annually causes ∼500,000 deaths among children aged <5 years. The primary site of rotavirus infection is the small intestine. Pathologic investigations of patients who died of rotavirus infection are limited to data from a few reported autopsies, and dehydration with electrolyte imbalance is believed to be the major cause of death. Several recent reports suggest that children who died during a rotavirus illness were viremic before death, because rotavirus was detected at several extraintestinal sites. We report 3 rotavirus-associated deaths among children, 2 of whom had evidence of rotavirus genome in extraintestinal tissues detected by use of novel molecular diagnostic methods. The part played by rotavirus in fatal cases is unclear and requires additional investigation of diarrhea-associated deaths, because a better understanding might alter the approach to treatment and the need for antiviral therapy.

Journal Article.  4263 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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