Journal Article

Improvement of Systemic Human Immunodeficiency Virus—Related Non-Hodgkin Lymphoma Outcome in the Era of Highly Active Antiretroviral Therapy

Emanuela Vaccher, Michele Spina, Renato Talamini, Martina Zanetti, Giampiero di Gennaro, Guglielmo Nasti, Marcello Tavio, Daniele Bernardi, Cecilia Simonelli and Umberto Tirelli

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 37, issue 11, pages 1556-1564
Published in print December 2003 | ISSN: 1058-4838
Published online December 2003 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/379517
Improvement of Systemic Human Immunodeficiency Virus—Related Non-Hodgkin Lymphoma Outcome in the Era of Highly Active Antiretroviral Therapy

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To assess the impact of highly active antiretroviral therapy (HAART) on the outcome of systemic human immunodeficiency virus—related non-Hodgkin lymphoma (HIV-NHL), we retrospectively analyzed 235 patients in whom HIV-NHL was diagnosed from April 1988 through December 1999. A multivariate Cox proportional hazards model was used to estimate prognostic factors for overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Complete remission occurred in 49% of patients, and the 3-year rates of OS, PFS, and DFS were 19%, 49%, and 73%, respectively. The greatest risk for shortened OS, PFS, and DFS was associated with no HAART use (compared with long-term HAART use); hazard ratios were 17.42 (95% confidence interval [CI], 17.42–40.25), 9.11 (95% CI, 3.71–22.32), and 8.54 (95% CI, 1.19–61.11), respectively. Our study suggests that the long-term use of HAART may favorably change the outcome for patients with systemic HIV-NHL.

Journal Article.  4506 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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