Journal Article

Autoantibodies to Interferon-γ in a Patient with Selective Susceptibility to Mycobacterial Infection and Organ-Specific Autoimmunity

Rainer Döffinger, Matthew R. Helbert, Gabriela Barcenas-Morales, Kun Yang, Stephanie Dupuis, Lourdes Ceron-Gutierrez, Clara Espitia-Pinzon, Neil Barnes, Graham Bothamley, Jean-Laurent Casanova, Hilary J. Longhurst and Dinakantha S. Kumararatne

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 1, pages e10-e14
Published in print January 2004 | ISSN: 1058-4838
Published online January 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/380453
Autoantibodies to Interferon-γ in a Patient with Selective Susceptibility to Mycobacterial Infection and Organ-Specific Autoimmunity

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We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.

Journal Article.  2409 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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