Journal Article

Multidrug-Resistant <i>Escherichia coli</i> Clonal Groups Causing Community-Acquired Pyelonephritis

Amee R. Manges, Peter S. Dietrich and Lee W. Riley

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 3, pages 329-334
Published in print February 2004 | ISSN: 1058-4838
Published online February 2004 | e-ISSN: 1537-6591 | DOI:
Multidrug-Resistant Escherichia coli Clonal Groups Causing Community-Acquired Pyelonephritis

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From October 1999 through January 2000, an Escherichia coli clonal group (designated “CgA”) was isolated from the urine of nearly one-half of all women with urinary tract infections (UTIs) caused by trimethoprim-sulfamethoxazole (TMP-SMZ)–resistant E. coli in a California community. This study describes the prevalence of pyelonephritis caused by CgA in the same community. E. coli isolates were characterized by enterobacterial repetitive intergenic consensus (ERIC2) polymerase chain reaction (PCR), serogrouping, and pulsed-field gel electrophoresis. Fourteen (11%) of 130 women with UTIs received a diagnosis of pyelonephritis. CgA was associated with 4 (57%) of the 7 pyelonephritis cases caused by TMP-SMZ–resistant E. coli and was associated with none of the cases caused by TMP-SMZ–susceptible E. coli (P < .02). Six (86%) of these TMP-SMZ–resistant E. coli isolates belonged to 2 distinct ERIC2 PCR–defined clonal groups, whereas all of the TMP-SMZ–susceptible E. coli strains had unique fingerprints (P < .001). The prevalence of antimicrobial-resistant pyelonephritis in a community may be affected by a limited number of E. coli clonal groups.

Journal Article.  2945 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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