Journal Article

<i>Blastoschizomyces capitatus</i> Infection in Patients with Leukemia: Report of 26 Cases

Rodrigo Martino, Miguel Salavert, Rocío Parody, José F. Tomás, Rafael de la Cámara, Lourdes Vázquez, Isidro Jarque, Elena Prieto, José Luis Sastre, Ignacio Gadea, Javier Pemán and Jorge Sierra

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 3, pages 335-341
Published in print February 2004 | ISSN: 1058-4838
Published online February 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/380643
Blastoschizomyces capitatus Infection in Patients with Leukemia: Report of 26 Cases

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Twenty-six cases of Blastoschizomyces capitatus infection were diagnosed in 25 patients at 7 tertiary care hematology units in Spain over a 10-year period. Most patients (92%) had acute leukemia and developed infection during a period of severe and prolonged neutropenia. Two patients had esophagitis, and the rest had invasive infection. Fungemia (20 cases) was a common finding, with frequent visceral dissemination. The 30-day mortality associated with this infection was 52%, compared with 57% among patients with systemic infection. In a univariate analysis, the following 3 variables had a positive impact on 30-day survival: removal of the central venous catheter within 5 days after the onset of infection (P = .02), a good performance status (P = .003), and receipt of systemic prophylactic or empirical antifungal therapy before infection onset (P = .006). Outcome for neutropenic patients with B. capitatus infection is still poor. Rapid removal of the central venous catheter and novel antifungal therapies are recommended for treatment of this rare infection.

Journal Article.  3090 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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