Journal Article

Malabsorption of Rifampin and Isoniazid in HIV-Infected Patients With and Without Tuberculosis

Prema Gurumurthy, Geetha Ramachandran, A. K. Hemanth Kumar, S. Rajasekaran, C. Padmapriyadarsini, Soumya Swaminathan, P. Venkatesan, L. Sekar, S. Kumar, O. R. Krishnarajasekhar and P. Paramesh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 2, pages 280-283
Published in print January 2004 | ISSN: 1058-4838
Published online January 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/380795
Malabsorption of Rifampin and Isoniazid in HIV-Infected Patients With and Without Tuberculosis

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The absorption of rifampin, isoniazid, and D-xylose in patients with human immunodeficiency virus (HIV) infection and diarrhea, in patients with HIV infection and tuberculosis (TB), in patients with pulmonary TB alone, and in healthy subjects was studied. Percentage of dose of the drugs, their metabolites, and D-xylose excreted in urine were calculated. A significant reduction in the absorption of drugs and D-xylose in both the HIV infection/diarrhea and HIV infection/TB groups was observed (P < .05), and the correlation between them was significant. Our results indicate that patients with HIV infection and diarrhea and those with HIV infection and TB have malabsorption of rifampin and isoniazid.

Journal Article.  2527 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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