Journal Article

Clinical Features Associated with Bacteremia Due to Heterogeneous Vancomycin-Intermediate <i>Staphylococcus aureus</i>

Patrick G. P. Charles, Peter B. Ward, Paul D. R. Johnson, Benjamin P. Howden and M. Lindsay Grayson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 3, pages 448-451
Published in print February 2004 | ISSN: 1058-4838
Published online February 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381093
Clinical Features Associated with Bacteremia Due to Heterogeneous Vancomycin-Intermediate Staphylococcus aureus

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We assessed all episodes of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia at our hospital during a 12-month period (n = 53) and compared those due to heterogeneous vancomycin-intermediate S. aureus (hVISA; n = 5, 9.4%) with those due to vancomycin-susceptible MRSA (n = 48). Patients with hVISA bacteremia were more likely to have high bacterial load infections (P = .001), vancomycin treatment failure (persistent fever and bacteremia for >7 days after the start of therapy; P < .001), and initially low serum vancomycin levels (P = .006). These clinical markers of hVISA bacteremia may help focus diagnostic efforts and treatment.

Journal Article.  2237 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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