Journal Article

Sarcoidosis in HIV-Infected Patients in the Era of Highly Active Antiretroviral Therapy

Guillaume Foulon, Marie Wislez, Jean-Marc Naccache, François-Xavier Blanc, Antoine Rabbat, Israël-Biet Dominique, Valeyre Dominique, Charles Mayaud and Jacques Cadranel

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 3, pages 418-425
Published in print February 2004 | ISSN: 1058-4838
Published online February 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381094
Sarcoidosis in HIV-Infected Patients in the Era of Highly Active Antiretroviral Therapy

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To analyze the impact of highly active antiretroviral therapy (HAART) on the characteristics and outcome of sarcoidosis in patients infected with human immunodeficiency virus (HIV), we identified HIV-infected patients in whom sarcoidosis was diagnosed between 1996 and 2000 from the admission registers of the pneumology departments of 12 hospitals in the Paris region (France). Sarcoidosis was diagnosed in 11 HIV-infected patients, of whom 8 were receiving HAART. HIV infection was diagnosed before sarcoidosis in 9 cases. At diagnosis of sarcoidosis, the mean CD4 cell count (±SD) was 390 ± 213 cells/mm3, and the mean plasma virus load was 4002 ± 10,183 copies/mL. Sarcoidosis occurred several months after HAART introduction, when the CD4 cell count had increased and the plasma HIV load had decreased. Clinical and radiological characteristics, laboratory values for bronchoalveolar lavage fluid samples, and outcome after a long follow-up were similar for the patients receiving HAART and for HIV-uninfected patients.

Journal Article.  3937 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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