Journal Article

Unusual Presentation of Life-Threatening Toscana Virus Meningoencephalitis

Franco Baldelli, Maria Grazia Ciufolini, Daniela Francisci, Antonella Marchi, Giulietta Venturi, Cristiano Fiorentini, Maria Laura Luchetta, Lidia Bruto and Sergio Pauluzzi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 4, pages 515-520
Published in print February 2004 | ISSN: 1058-4838
Published online February 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381201
Unusual Presentation of Life-Threatening Toscana Virus Meningoencephalitis

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This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase—polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.

Journal Article.  3449 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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