Journal Article

Antiretroviral Therapy and the Clinical Evolution of Human Papillomavirus–Associated Genital Lesions in HIV-Positive Women

Annarosa Del Mistro, Roberta Bertorelle, Marzia Franzetti, Annamaria Cattelan, Angela Torrisi, Maria Teresa Giordani, Roberto Sposetti, Emanuela Bonoldi, Lolita Sasset, Laura Bonaldi, Daria Minucci and Luigi Chieco-Bianchi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 5, pages 737-742
Published in print March 2004 | ISSN: 1058-4838
Published online March 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381681
Antiretroviral Therapy and the Clinical Evolution of Human Papillomavirus–Associated Genital Lesions in HIV-Positive Women

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The effect of antiretroviral therapy on the natural history of human papillomavirus (HPV)–associated genital lesions was evaluated in 201 human immunodeficiency virus (HIV)–infected women who were followed-up for 1–6 years. Gynecologic examinations were performed every 6–12 months. HPV sequences in cervico-vaginal cells, analyzed by polymerase chain reaction and typed by restriction fragment–length polymorphism analysis, were repeatedly detected in 126 women; 29 had transient HPV infection. Genital lesions were found in 137 patients; prevalence was comparable in women who were receiving different antiretroviral regimens. Regression of low-grade lesions was more prevalent among patients receiving highly active antiretroviral therapy than among those receiving other regimens; high-grade lesions regressed in the majority of cases, regardless of antiretroviral therapy. HPV infection persisted in nearly 80% of the cases. In conclusion, our data show that antiretroviral therapy does not prevent the development of HPV-associated lesions and does not eliminate HPV infection; therefore, early and strict gynecologic follow-up of HIV-infected women is warranted.

Journal Article.  4120 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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