Journal Article

Elevated Concentrations of CCL2 and Tumor Necrosis Factor—α in Chagasic Cardiomyopathy

André Talvani, Manoel O. C. Rocha, Lucíola S. Barcelos, Yara M. Gomes, Antônio L. Ribeiro and Mauro M. Teixeira

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 7, pages 943-950
Published in print April 2004 | ISSN: 1058-4838
Published online April 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381892
Elevated Concentrations of CCL2 and Tumor Necrosis Factor—α in Chagasic Cardiomyopathy

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Chronic myocarditis is the main pathological finding associated with Chagas disease—related morbidity. Concentrations of CCL2, CCL3, tumor necrosis factor (TNF)—α, and brain natriuretic peptide (BNP) were evaluated in plasma samples obtained from patients with different clinical forms of chronic chagasic cardiomyopathy. Patients with more-severe Chagas disease had elevated plasma concentrations of TNF-α, CCL2, and BNP, and there was a good correlation between levels of these proteins (especially TNF-α) and the degree of heart dysfunction. Indeed, TNF-α level was an excellent predictor of heart failure. Peripheral blood mononuclear cell samples obtained from patients with mild or severe chagasic cardiomyopathy produced greater amounts of TNF-α and CCL2 than did those obtained from noninfected individuals. The elevation of TNF-α and CCL2 levels in the plasma of patients appears to be secondary to the degree of heart dysfunction, whereas spontaneous production of TNF-α and CCL2 by mononuclear cells is secondary not only to heart dysfunction, but also to the underlying inflammation in the heart of chagasic patients. Measurement of the TNF-α level could be a useful tool in the identification of patients with heart dysfunction who may benefit from further investigation and treatment.

Journal Article.  4552 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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