Journal Article

<i>Rickettsia parkeri:</i> A Newly Recognized Cause of Spotted Fever Rickettsiosis in the United States

Christopher D. Paddock, John W. Sumner, James A. Comer, Sherif R. Zaki, Cynthia S. Goldsmith, Jerome Goddard, Susan L. F. McLellan, Cynthia L. Tamminga and Christopher A. Ohl

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 6, pages 805-811
Published in print March 2004 | ISSN: 1058-4838
Published online March 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381894
Rickettsia parkeri: A Newly Recognized Cause of Spotted Fever Rickettsiosis in the United States

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Ticks, including many that bite humans, are hosts to several obligate intracellular bacteria in the spotted fever group (SFG) of the genus Rickettsia. Only Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, has been definitively associated with disease in humans in the United States. Herein we describe disease in a human caused by Rickettsia parkeri, an SFG rickettsia first identified >60 years ago in Gulf Coast ticks (Amblyomma maculatum) collected from the southern United States. Confirmation of the infection was accomplished using serological testing, immunohistochemical staining, cell culture isolation, and molecular methods. Application of specific laboratory assays to clinical specimens obtained from patients with febrile, eschar-associated illnesses following a tick bite may identify additional cases of R. parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States.

Journal Article.  4369 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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