Journal Article

Clinical Manifestations and Molecular Epidemiology of Necrotizing Pneumonia and Empyema Caused by <i>Streptococcus pneumoniae</i> in Children in Taiwan

Yu-Chia Hsieh, Po-Ren Hsueh, Lu Chun-Yi, Ping-Ing Lee, Chin-Yun Lee and Li-Min Huang

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 6, pages 830-835
Published in print March 2004 | ISSN: 1058-4838
Published online March 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/381974
Clinical Manifestations and Molecular Epidemiology of Necrotizing Pneumonia and Empyema Caused by Streptococcus pneumoniae in Children in Taiwan

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Recently, there have been increasing numbers of pneumococcal pneumonia cases, with their associated complications. We conducted a retrospective review to increase the understanding of childhood pneumococcal pneumonia. Seventy-one patients with pneumococcal pneumonia were identified. Forty (56.3%) of them developed complicated pneumonia. Multivariate analysis showed that presence of immature polymorphonuclear leukocytes in peripheral blood (odds ratio [OR], 3.67; 95% confidence interval [CI], 1.08–12.63), high C-reactive protein levels (>12 mg/dL) (OR, 5.24; 95% CI, 1.10–24.93), and no underlying disease at presentation (OR, 5.48; 95% CI, 1.06–28.25) were independent predictors of the occurrence of necrosis or/and abscess. Fourteen isolates (35%), which were genotypically identical and had the same pulsed-field gel electrophoresis pattern (serogroup 14, with MICs of penicillin of 0.1–0.5 µg/mL), were significantly associated with complicated pneumonia (P = .047). Whether the virulence of antibiotic-resistant pneumococci is evolving deserves further investigation.

Journal Article.  3509 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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