Journal Article

False-Positive Galactomannan Platelia <i>Aspergillus</i> Test Results for Patients Receiving Piperacillin-Tazobactam

Claudio Viscoli, Marco Machetti, Paola Cappellano, Barbara Bucci, Paolo Bruzzi, Maria Teresa Van Lint and Andrea Bacigalupo

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 6, pages 913-916
Published in print March 2004 | ISSN: 1058-4838
Published online March 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/382224
False-Positive Galactomannan Platelia Aspergillus Test Results for Patients Receiving Piperacillin-Tazobactam

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At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P < .001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT (χ2 = 34.7; P < .001) and underlying disease (χ2 = 21.14; P < .001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.

Journal Article.  2448 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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