Journal Article

Changes in Hepatitis B Virus DNA Levels with Acute HIV Infection

Chloe L. Thio, Dale M. Netski, Jane Myung, Eric C. Seaberg and David L. Thomas

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 7, pages 1024-1029
Published in print April 2004 | ISSN: 1058-4838
Published online April 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/382534
Changes in Hepatitis B Virus DNA Levels with Acute HIV Infection

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We hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels. To test this hypothesis, we evaluated sequential HBV DNA levels in stored serum samples obtained from 9 men with CHB who acquired HIV infection. Three patterns of changes in HBV DNA levels were noted after HIV seroconversion. One man experienced the expected increase in HBV DNA, 3 men had stable HBV DNA levels, and, unexpectedly, 5 men had a mean decrease of 6.29 log10 copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in 4. Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection.

Journal Article.  3295 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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