Journal Article

Characterization of Group B Streptococci Recovered from Infants with Invasive Disease in England and Wales

Abbie M. Weisner, Alan P. Johnson, Theresa L. Lamagni, Eve Arnold, Marina Warner, Paul T. Heath and Androulla Efstratiou

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 9, pages 1203-1208
Published in print May 2004 | ISSN: 1058-4838
Published online May 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/382881
Characterization of Group B Streptococci Recovered from Infants with Invasive Disease in England and Wales

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Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes III (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype III strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.

Journal Article.  4249 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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