Journal Article

Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan

Fuminaka Sugauchi, Hiromitsu Kumada, Hiroshi Sakugawa, Masafumi Komatsu, Hirofumi Niitsuma, Hisayoshi Watanabe, Yoshihiro Akahane, Hajime Tokita, Takanobu Kato, Yasuhito Tanaka, Etsuro Orito, Ryuzo Ueda, Yuzo Miyakawa and Masashi Mizokami

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 9, pages 1222-1228
Published in print May 2004 | ISSN: 1058-4838
Published online May 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/382885
Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan

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We have previously reported 2 subtypes of hepatitis B virus (HBV) genotype B, one of which has the recombination with genotype C over the precore region plus core gene (Ba) and the other of which does not (Bj). A restriction fragment—length polymorphism method with 2 endonucleases was newly developed for distinguishing between subtypes Ba and Bj and was applied to 313 carriers of HBV genotype B in Japan. Subtype Ba was detected in 38 (12%) and subtype Bj in 275 (88%) of the carriers of HBV genotype B. Hepatitis B e antigen in serum was found more frequently in patients with chronic infection with subtype Ba than in those with chronic infection with subtype Bj (8 [32%] of 25 vs. 25 [9%] of 273; P < .01). The new method for distinguishing between Ba and Bj by restriction fragment—length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent.

Journal Article.  4346 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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