Journal Article

Detection of Influenza Antigen with Rapid Antibody-Based Tests after Intranasal Influenza Vaccination (FluMist)

Tanya Ali, Nathaniel Scott, Wendy Kallas, Mary Ellen Halliwell, Carol Savino, Eric Rosenberg, MaryJane Ferraro and Elizabeth Hohmann

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 5, pages 760-762
Published in print March 2004 | ISSN: 1058-4838
Published online March 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/382887
Detection of Influenza Antigen with Rapid Antibody-Based Tests after Intranasal Influenza Vaccination (FluMist)

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Rapid tests for influenza antigen detection are frequently used, but it is not known how receipt of intranasal influenza vaccine affects results of these tests. We tested healthy adults who received either intranasal or intramuscular influenza vaccine. Of the 14 intranasal vaccine recipients, 7 (50%) had a direct fluorescent antibody test (DFA) result and 2 (14%) had an enzyme immunoassay (EIA) result that was positive for influenza antigen within 7 days after vaccination. No subjects had positive EIA results on day 12 or 13 after vaccination. For some intranasal vaccine recipients, rapid influenza-antigen detection tests yield positive results within 1 week after vaccination.

Journal Article.  2065 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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