Journal Article

Effect of Macrolide Consumption on Erythromycin Resistance in <i>Streptococcus pyogenes</i> in Finland in 1997–2001

Miika Bergman, Solja Huikko, Marja Pihlajamäki, Pekka Laippala, Erkki Palva, Pentti Huovinen and Helena Seppälä

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 9, pages 1251-1256
Published in print May 2004 | ISSN: 1058-4838
Published online May 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/383309
Effect of Macrolide Consumption on Erythromycin Resistance in Streptococcus pyogenes in Finland in 1997–2001

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The aim of this study was to investigate the association between regional macrolide resistance in Streptococcus pyogenes and macrolide use in Finland. During 1997–2001, a total of 50,875 S. pyogenes isolates were tested for erythromycin susceptibility in clinical microbiology laboratories throughout Finland. The local erythromycin resistance levels were compared with the regional consumption data of all macrolides pooled and, separately, with the use of azithromycin. The regional resistance rates of 1 year were compared with the regional consumption of the previous year and with the average rates of use for the 2 previous years. A linear mixed model for repeated measures was used in modeling the association. A statistically significant association existed between regional erythromycin resistance in S. pyogenes and consumption of macrolides; association with azithromycin use alone was not found.

Journal Article.  3138 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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