Journal Article

<i>Fusarium</i> Infection in Hematopoietic Stem Cell Transplant Recipients

Marcio Nucci, Kieren A. Marr, Flavio Queiroz-Telles, Carlos A. Martins, Plínio Trabasso, Silvia Costa, Julio C. Voltarelli, Arnaldo L. Colombo, Alexander Imhof, Ricardo Pasquini, Angelo Maiolino, A. Souza Cármino and Elias Anaissie

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 9, pages 1237-1242
Published in print May 2004 | ISSN: 1058-4838
Published online May 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/383319
Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients

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To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21–5.0 cases per 1000 in human leukocyte antigen (HLA)—matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.

Journal Article.  3006 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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