Journal Article

Extensive Implementation of Highly Active Antiretroviral Therapy Shows Great Effect on Survival and Surrogate Markers in Vertically HIV–Infected Children

Salvador Resino, José Mª Bellón, Rosa Resino, Mª Luisa Navarro, José Tomás Ramos, Mª Isabel de José, Mª José Mellado and Mª ángeles Muñoz-Fernáendez

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 11, pages 1605-1612
Published in print June 2004 | ISSN: 1058-4838
Published online June 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/420738
Extensive Implementation of Highly Active Antiretroviral Therapy Shows Great Effect on Survival and Surrogate Markers in Vertically HIV–Infected Children

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We performed a retrospective observational study of 253 children vertically infected with human immunodeficiency virus (1994–2001) to assess the effectiveness of antiretroviral therapies (ARTs) on survival and surrogate markers at the population level. Children were divided into 3 groups according to the ART protocols used during the follow-up period: calendar period (CP) 1 (1994–1996) received combined therapy with 2 nucleoside reverse transcriptase inhibitors (NRTIs); CP2 (1997–1998) received implementation of highly active ART (HAART) with 3 drugs (NRTIs, protease inhibitors, and non-NRTIs); and CP3 (1999–2001) received extensive HAART. The children in the CP3 group had statistically significant longer survival periods, lower virus load (VL), highest undetectable VL proportion, and highest CD4+ T cell counts. HAART is effective at the population level at decreasing VL, increasing CD4+ T cells, and increasing the survival in a higher percentage of HIV-infected children.

Journal Article.  3968 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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