Journal Article

Hepatitis A and B Vaccination Practices for Ambulatory Patients Infected with HIV

Ellen M. Tedaldi, Rose K. Baker, Anne C. Moorman, Kathleen C. Wood, Jack Fuhrer, Robert E. McCabe and Scott D. Holmberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 38, issue 10, pages 1478-1484
Published in print May 2004 | ISSN: 1058-4838
Published online May 2004 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/420740
Hepatitis A and B Vaccination Practices for Ambulatory Patients Infected with HIV

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Few studies exist of adherence to guidelines for vaccination of persons infected with human immunodeficiency virus (HIV), especially in the era of highly active antiretroviral therapy (HAART). In a retrospective, cross-sectional analysis in the HIV Outpatient Study sites, 198 (32.4%) of 612 patients eligible for hepatitis B vaccine received at least 1 dose. In multivariate analysis, hepatitis B vaccination was associated with HIV risk category, education level, and number of visits to the HIV clinic per year. Among 716 patients eligible for hepatitis A vaccine, 167 (23.3%) received ⩾1 dose. Response to hepatitis B vaccination was associated with higher nadir CD4+ cell counts (P = .008) and HIV RNA levels less than the level of detection (P = .04), although some response was documented at all CD4+ levels. Although there were low rates of complete hepatitis vaccination in this cohort of ambulatory patients, prompt efforts to vaccinate patients entering care, receipt of antiretroviral therapy, and practice reminder systems may enhance vaccination practices.

Journal Article.  4204 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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